SMAD3 and Agnathia - holoprosencephaly - situs inversus: For instance, the SMAD3 gene was reported to cause prenatal agnathia-otocephaly complex in contrast to postnatal aortic aneurysm, cardiac anomalies, cleft palate and micro/retrognathia (Loeys-Dietz syndrome 3, OMIM#613795) [38].