The dissociation of p53INP from p53 attenuates PKCδ-mediated p53 Ser46 phosphorylation, which suppresses p53 transcriptional activity, downregulates proapoptotic and ferroptotic target genes of p53, inhibits p53-mediated apoptosis and ferroptosis, and promotes HCC initiation and progression (Fig. 8). The gene discussed is PRKCD; the disease is hepatocellular carcinoma.