Compared to the other cancer types, ATAC-seq samples of the DIAD and kidney carcinoma classes as well as those of the liver-associated cancer types, including liver hepatocellular carcinoma (LIHC) and cholangiocarcinoma (CHOL), showed clearly higher HNF4A activity scores (Fig. 6g). This evidence concerns the gene HNF4A and cholangiocarcinoma.