SOD2 and lung cancer: In previous studies, it was shown that dietary flavone K (3,5,7-trihydroxy-2—(4-hydroxyphenyl)—4-chromenone) can effectively prevent and treat lung cancer, mainly through the following mechanisms: (1) K inhibits the apoptosis of H460 cells (NSCLC cells) by inducing the overexpression of tumor suppressor gene antioxidant enzyme (Sod-2) [66].