TARDBP and amyotrophic lateral sclerosis: While clinical observations on a subgroup of ALS patients have shown cytoplasmic TDP-43 localisation in non-neuronal cell types, including fibroblasts [82], lymphomonocytes, and monocytes/macrophages [83, 84], abnormal TDP-43/pTDP-43 cytosolic inclusions (skein-like, granular) to date, have not been reported.