Interestingly, out of 11 ALS MDMi examined, we found 100% (4 out of 4 slow cases), 67% (2 out of 3 intermediate cases) and 50% (2 out of 4 rapid cases) that showed a reduction of TDP-43 in the nucleus and a corresponding increase in the cytoplasm. Here, TARDBP is linked to amyotrophic lateral sclerosis.