To explore the prognostic significance of the SPAG family members (SPAG1/2/3/4/5/6/7/9/10/13/16/17) in AML, we first determined the impact of each SPAG member on survival time (both OS and LFS) by Cox regression univariate analysis among AML in TCGA datasets. The gene discussed is RPAP3; the disease is acute myeloid leukemia.