SPAG1 and acute myeloid leukemia: Furthermore, Kaplan–Meier analysis also revealed that AML patients with higher SPAG1 expression showed significantly shorter OS and LFS than those with lower SPAG1 expression among AML (both P < 0.001), non-M3 AML (both P < 0.001), and CN-AML (both P = 0.004) patients (Fig. 1a and b).In addition, the expression of SPAG1 was upregulated in AML patients, as analyzed by GEPIA (Fig. 1c).