For GSE6891 and GSE37642, Kaplan–Meier analysis showed that AML patients with higher SPAG1 expression had strikingly shorter EFS and/or OS times than those with lower SPAG1 expression (P = 0.025, 0.0025 and 0.045, respectively, Fig. 1e). This evidence concerns the gene SPAG1 and acute myeloid leukemia.