We found that people developed VER tend to have these clinical factors: the performance of major resection, lymph node dissection, tumor size> = 5 cm, the presence of MiVI, MaVI, and SN, GGT> = 75 U/L, ALP > = 78 U/L, AFP > = 20 ng/mL, CA19-9 > = 25 U/mL, and DCP > = 200 mAU/mL. The gene discussed is AFP; the disease is neoplasm.