Although previous studies have shown that SERPINH1 is a potential molecular marker and therapeutic target for many tumors including gastric cancer [38], hepatocellular carcinoma [21], cervical squamous cell carcinoma [39], renal cell carcinoma [40], and head and neck squamous cell carcinoma [41], the mechanism by which SERPINH1 affects tumor progression through the production of collagen is unclear. This evidence concerns the gene SERPINH1 and head and neck squamous cell carcinoma.