HMGB1 and neoplasm: Efimova et al. first proved that ferroptosis is immunogenic in vitro/ vivo, and ATP and HMGB1, the most prominent damage-associated molecules, have been authenticated to be passively released follow the time line of ferroptosis and as immunogenic molecules are tightly related to the immunogenicity of early ferroptotic tumor cells, this implies that ferroptosis is cardinal for the immunotherapy efficacy [37, 38].