In order further to determine the role of HOTAIR/miR-106a-5p/SOX4 axis in NPC DDP-resistant, the results of nude mice experiment showed that silencing HOTAIR or si-SOX4 decreased tumor growth, while the miR-106a-5p inhibitor promoted tumor growth (P < 0.05; Figure 7(a–f)). The gene discussed is SOX4; the disease is neoplasm.