ICAM1 and metastatic melanoma: Coxsackievirus A21 (CVA21, CAVATAK, V937) is an unaltered RNA virus that can selectively infect tumor cells by entry through intercellular adhesion molecule-1 (ICAM-1) and decay-accelerating factor (DAF), which are both overexpressed in metastatic melanoma and other malignancies [34,39,40].