For example, CXCL12/CXCR7 can activate Rho/ROCK pathway and promote the migration and invasion of pancreatic cancer cells [38]; CXCL12/CXCR7 promotes the malignancy of renal cancer cells by activating mTOR signaling pathway [39]. This evidence concerns the gene CXCL12 and familial pancreatic carcinoma.