Interestingly, Foxf2, Foxq1 and Exoc2 were all significantly up‐regulated in conditional Smo+/M2 gain‐of‐function mice, indicating these genes are targets of SHH‐SMO signalling (Hammond et al., 2018); however, whether these genes contribute to the pathogenesis of cleft palate in Foxf2−/− or conditional Smo+/M2 mice requires further investigation. This evidence concerns the gene SMO and cleft palate.