RBM20 and dilated cardiomyopathy: We also found RBM20, which has been shown to have rare inherited variants causing human dilated cardiomyopathy [38–40], to be overexpressed in both iPSC-CVPC and adult heart compared with adult arteria (respectively, p = 1.5 x 10−30 and p = 1.3 x 10−55, Fig 1I), consistent with its predominant expression in striated muscle [41].