SH2D3C and infection: This could be advantageous for PRRSV, for example, if there is a greater requirement for nsp2 and nsp3, which promote DMV formation (Snijder et al., 2001), early in infection to establish a protective environment for viral replication, followed by a later preference for producing more of the RdRp (nsp9) and helicase (nsp10) to promote replication itself.