LTF and Granuloma: Here, the effect of lactoferrin on the permeability of primary granulomas (non-necrotic) to a fluoroquinolone is examined in the Mtb-infected C57Bl/6 mouse model, when lactoferrin is administered as a prophylactic (defined as when given prior to granuloma formation) or therapeutic (defined as when given after granuloma establishment) intervention.