PDCD1 and cancer: We further stratified patient groups using BMI along with TMB, which is associated with response to ICB in many cancer types.4 The high TMB group was defined by the cutoff of greater than 10 mutations per megabase, which was approved by the FDA as a biomarker for anti–programmed cell death 1.5 Patients with BMI of 30 or higher had better OS after ICB treatment than patients with BMI of less than 30 in the TMB greater than 10 group (HR, 0.64; 95% CI, 0.47-0.89) and in the TMB less than 10 group (HR, 0.74; 95% CI, 0.64-0.85) (Figure 2, A).