This was demonstrated in a mouse model, where the co-administration of Rapamycin (an inhibitor of mTOR) and Mirdametinib (an inhibitor of MEK) inhibited hormone-refractory PCa cell growth, demonstrating the interdependence of the Ras and AKT signaling cascades in advanced PCa [29]. The gene discussed is AKT1; the disease is posterior cortical atrophy.