It decreases lung cancer invasion by inhibiting the S100A4/NF-B/MMP9 axis: 350 reduces both the breast cancer cell pulmonary metastases and metastatic potential of lapatinib-resistant breast cancer cells by inhibiting the STAT3-FAK-Src axis [215] and epithelial-mesenchymal transition (EMT) [216], respectively. This evidence concerns the gene S100A4 and breast carcinoma.