POLR3B and hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism: Thus, the HLD8-associated mutation of POLR3B proteins affects oligodendroglial cell morphological differentiation possibly through decreased lysosome-related mTOR signaling, and treatment with ibuprofen can cause its amelioration in glial cells such as oligodendroglial cells.