POLR3B and hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism: Hypomyelinating Leukodystrophy 8 (HLD8)-Associated Mutation of POLR3B Leads to Defective Oligodendroglial Morphological Differentiation Whose Effect Is Reversed by Ibuprofen