As shown in Figure 8, NK cells pre-complexed with EpCAM-specific ICE® constructs or anti-EpCAM control antibodies were effective in inducing lysis of the EpCAM+ HCC-1187 cells, whilst they were inactive against the EpCAM−/CD30+ KARPAS-299 cells. The gene discussed is TNFRSF8; the disease is hepatocellular carcinoma.