Since all EpCAM-specific ICE® constructs have an identical anti-EpCAM Fv domain in their Fab arms and bind to EpCAM on tumor cells equally well, the biological activity of bridging tumor cells with the effector NK cells by these constructs is expected to be determined by the specificity and affinity of NK cell recruiting domains to NK cell receptors. The gene discussed is KLRD1; the disease is neoplasm.