Among the EpCAM-specific ICE® constructs, NK cells pre-complexed with the EpCAM/CD16A ICE® displayed the highest efficacy in lysing the HCC-1187 cells (74.8%), with the EpCAM/NKp46 ICE® medium efficacy (46.1%), and with the EpCAM/NKG2D ICE® the lowest efficacy (14.3%) (Table 8). This evidence concerns the gene NCR1 and hepatocellular carcinoma.