However, although anti-EpCAM IgG1 was highly effective in inducing EpCAM-specific tumor cell lysis, its potency was substantially lower compared with that of the EpCAM/CD16A and EpCAM/NKp46 ICE® constructs and anti-EpCAM Fc-enhanced IgG1 (Table 7). The gene discussed is EPCAM; the disease is neoplasm.