CD274 and autoimmune disease: Our study showed that TP changed the expression patterns of surface molecules and secreted cytokines by DCs, downregulating CD80/86, ICAM-1, MHCI, TLR2/4, TNF-α, and IL-6 expression and upregulating PDL1 and IL-10 expression; these effects converted DCs into tolerogenic DCs and were crucial for the maintenance of immune homeostasis and the control of autoimmune disorders (Li et al., 2016).