CAVIN3 and lung carcinoma: In addition, the ROC curve results of tumor tissues and para-tumor tissues in the TCGA database also showed that PRKCDBP methylation was a potential diagnostic biomarker for lung cancer (AUC=0.686, P=3E-6, 95%CI: 0.612-0.760, sensitivity=57.94%, Specificity=81.30%, Fig 4E).