Paired comparison of PRKCDBP methylation levels showed that the methylation level of tumor tissues and 3 cm para-tumor tissues was higher than that of distant non-tumor tissues (tumor tissues vs distant non-tumor tissues: Padjusted < 0.001; 3 cm para-tumor tissues vs distant non-tumor tissues: Padjusted=0.05; Fig 2A). The gene discussed is CAVIN3; the disease is neoplasm.