Moreover, deletion of GPR54 or ERK5 in PSMA‐CAR‐T cells increased the cytotoxicity of PSMA‐overexpressing PC3 cells (human prostate adenocarcinoma cells) at a low effector‐to‐target ratio (Figure 7J), as well as TNFα release at an effector‐to‐target ratio of 1:1 (Figure 7K). Here, TNF is linked to prostate adenocarcinoma.