Chronic stress is associated with aberrant persistent activation of SNS and the HPA axis, leading to enhanced production of cortisol and catecholamines.[5] Previous studies have shown that SNSs play a crucial role in regulating immune cell development, such as myelopoiesis,[21] and lymphocyte differentiation.[22] Studies have shown that chronic stress promotes cancer progression by regulating DCs,[3] NKs,[5] iNKTs,[17] MDSCs,[23] and myeloid cells.[24] However, the mechanism by which chronic stress affects CD8+ T cells in tumor immune microenvironments is not completely understood. The gene discussed is CD8A; the disease is cancer.