OCLN exerted a proangiogenic effect on BLCA cells and regulated tube formation by endothelial cells cultured with CM derived from 5637 and T24 cells by altering IL8 levels (Figures 2C,F,G and 3F,G), indicating that OCLN promotes tumour neovascularization through IL8. This evidence concerns the gene CXCL8 and neoplasm.