Based on these findings, we set out to compare the effects of gefitinib in combination with IGF‐1R inhibitor ADW742, FGFR inhibitor BGJ398, BV‐6, or SGI‐1027 in three additional HNSCC models (UM‐SCC‐49, −92, and − 97). The gene discussed is IGF1R; the disease is head and neck squamous cell carcinoma.