Moreover, Liu et al. found that tumor-cell-derived lactate actively downregulates the expression of the macrophage lysosomal gene V-type proton ATPase subunit d2 (ATP6V0D2) via mTOR-dependent inhibition of TFEB, which subsequently targets HIF-2α for lysosome-mediated degradation [66]. This evidence concerns the gene EPAS1 and neoplasm.