Yu et al. revealed that histone lactylation promotes tumorigenesis by facilitating the transcription of YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2), which recognizes the m6A modification site in the mRNA of two tumor suppressor genes, PER1 and TP53, and promotes their degradation in ocular melanoma [42]. This evidence concerns the gene YTHDF2 and ocular melanoma.