It is important to consider that these latter findings were obtained from a population of patients with severe and suicidal PPD (e.g., symptoms that required hospitalization) suggesting that more severe depressive symptoms may be characterized by a different cytokine profile than less severe cases of PPD, as Bränn et al. (86) found no alterations in IL-6 and IL-8. This evidence concerns the gene CXCL8 and progressive pseudorheumatoid arthropathy of childhood.