Many of the up-regulated lncRNAs found by this methodological approach have been already identified and shown to be associated with IBD pathogenesis (Supplementary Table 2), such as small integral membrane protein 25 (SMIM25) [60], IFNG antisense RNA 1 (IFNG-AS1) [61], and DIO3 opposite strand RNA (DIO3OS) [62]. This evidence concerns the gene IFNG-AS1 and inflammatory bowel disease.