The expression of PTPRC (CD45), a known IBD susceptibility gene, correlated positively with lncRNA AC110611.2 and correlated negatively with six lncRNAs depicted in Fig. 4B. Here, the lncRNAs might contribute to the activation of Cd4+ T cells which are key players in mediating the host protective and homeostatic responses to inflammation [53]. This evidence concerns the gene CD4 and inflammatory bowel disease.