Importantly, this analysis revealed that the percentage of PJS patients with GC harboring STK11 mutations in region aa 107–170 was significantly higher (7/41, 17%) than the percentage of patients with STK11 mutations in region aa 49–106 (0/26, 0%) (P = 0.0375) or region aa 171–309 (3/70, 4.2%) (P = 0.0437) (Fig. S1B). Here, STK11 is linked to Peutz-Jeghers syndrome.