However, in HT patients, the frequencies of intrathyroidal CD4+CXCR5+ICOShigh and CD4+CXCR5+PD-1+ T cells were significantly elevated in patients with a longer disease duration (>1 year) compared with those newly diagnosed (≤1 year) (P = 0.0081, P = 0.0277) (Figure 5(d)). Here, CXCR5 is linked to hematocrit.