SIRT6 and myocardial infarction: For example, Tang et al. [31] found that two tag SNPs, rs352493 and rs3760908, within SIRT6 gene were associated with the severity of CAD in a Chinese Han population, and Wang showed that the two SNPs of SIRT6 gene promoter had significantly higher frequencies in MI patients than in controls, indicating that DSVs in MI patients may alter the transcriptional activity of the SIRT6 gene promoter and alter SIRT6 levels, thereby probably contributing to the risk of MI [32].