SIRT6 and coronary artery disorder: Figure 1 shows the LD block of rs350846/rs107251/rs350844 for SIRT6 gene; it presents a strong LD (rs350846/rs107251: D′ = 0.69, r2 = 0.46; rs107251/rs350844: D′ = 0.69, r2 = 0.46; rs350846/rs350844: D′ = 1, r2 = 0.97). The haplotype frequencies are presented in Table 4. The results demonstrate that haplotype CTA significantly increases the risk of CAD (P = 0.000118, OR = 1.497, 95%CI = 1.218–1.840), whereas haplotype GCG significantly decreases the risk of CAD (P = 0.000414, OR = 1.131, 95%CI = 0.791–1.619).