RNA-seq analysis confirmed an elevated expression of ABCA1 and ABCG1, whereas ISGs including IFIT1, IFIT3, OASL, and CXCL10 were suppressed in untreated FH monocytes compared to monocytes from healthy donors (FDR < 0.05, Figure 4E). The gene discussed is IFIT3; the disease is familial hyperaldosteronism.