Additionally, we examined the EGFR, MAPK, and AKT pathways in the rat MI models and found that the phosphorylation levels of EGFR, ERK, JNK, p-38, and AKT were significantly increased in the ADAMTS8 overexpression MI group compared with the scramble MI group (Figure 8F). This evidence concerns the gene ADAMTS8 and myocardial infarction.