Lens opacity 10 (Lop10) mutation at chromosome 3 and a missense single transversion (G-to-C) in the Cx50 coding region was identified in a mouse that developed microphthalmia with dense cataracts, resulting in Gly-to-Arg substitution at codon 22 (Chang et al., 2002). This evidence concerns the gene GJA8 and cataract.