Although the pathogenesis of cataracts is not yet fully clear (Davison, 2020; Hashemi et al., 2020; Shiels and Hejtmancik, 2021; Taylan Sekeroglu and Utine, 2021), a number of studies have shown that disruption of lens connexin hemichannels proteins Cx46 and Cx50 expression are associated with cataract formation (White et al., 1998; Chang et al., 2002; Addison et al., 2006; Xia et al., 2006a). The gene discussed is GJA8; the disease is cataract.