Under normal circumstances, the activation of PI3K/Akt pathway in tumor cells can trigger the increase of intracellular ROS and promote tumor malignant transformation, but ROS overload can reverse the activation of PI3K/Akt pathway through the expression of PTEN (Jaramillo and Zhang, 2013; Jang et al., 2016; Wu et al., 2020). The gene discussed is AKT1; the disease is neoplasm.