This leads to a blockage in the degradation of the α subunit of hypoxia-inducible transcription factors (HIF1 and HIF2) (Gossage et al., 2015), which results in increased expression of angiogenic factors including VEGF that plays a significant role in the growth and progression of RCC (Gudas et al., 2014). Here, VEGFA is linked to renal cell carcinoma.