A study reported that overexpression of circ-FNDC3B may weaken the effects of curcumin on inhibiting proliferation and promoting apoptosis of RCC cell through regulating the miR-138-5p/IGF2 axis, which provides a new perspective for the treatment of renal cell carcinoma (Xue et al., 2021). The gene discussed is IGF2; the disease is renal cell carcinoma.