Although several genes have been associated with the occurrence and development of renal cancer, such as BAP1, BIRC5, CXCR4, and SETD2 (Petitprez et al., 2021), there are other undiscovered genes that can be used as markers of ccRCC, which can provide new insights into the mechanism of occurrence and development of ccRCC. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.