GRK5 can regulate GPCR signaling, which correlates with various diseases like cardiac dysfunction, diabetes, hypertension, Alzheimer’s disease, and cancers (Kim et al., 2012; Komolov et al., 2017; Jiang et al., 2018; Alshabi et al., 2019; Zhao et al., 2019b). This evidence concerns the gene GRK5 and cancer.