The bioactivity of these melanoidins was evaluated by in vitro antioxidant methods and for the first time their cytotoxic effect was tested in two human cancer cell lines, namely Caco-2 and HepG2; in addition, the antidiabetic, antiaging, and neurobiological activities were evaluated in vitro by assessing their inhibitory activity against α-amylase, α-glucosidase, elastase, tyrosinase, and acetylcholinesterase (AChE). This evidence concerns the gene ACHE and cancer.