Interestingly, in lymphoblasts isolated from human chronic myelogenous leukaemia (K562), which express traces of VISTA, this expression (unlike in MCF-7 cells where no VISTA protein expression is detected at all) can be induced by 24 h of exposure to 2 ng/ml TGF-β where this concentration appears to be the most effective (Figure 1K). The gene discussed is TGFB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.