Performing both tissue and plasma testing resulted in a diagnostic finding in 42.6% (23/54) of NSCLC cases, considering only tissue EGFR test and plasma NGS test not including ALK, RET, ROS1 fusions among actionable targets, which represents a 1.9-fold increase in the number of actionable findings compared to tissue EGFR testing alone. This evidence concerns the gene ALK and non-small cell lung carcinoma.