As an attestation of the specificity and broad applicability of plasma NGS for cancer diagnostics, we also show that among other suspected lung cancer patients eventually diagnosed to not have cancer, only one case (out of 10) had a detectable mutation (of uncertain significance), while six of seven cases diagnosed as having other non-NSCLC cancers had TP53 mutations or other cancer-related mutations detected. Here, TP53 is linked to cancer.