Besides this, we explored the correlation between ITGB5 expression and gene markers of macrophage, and the ITGB5 expression was significantly correlated with macrophage markers, including M1 macrophage markers (NOS2, IL1B, CD86), M2 macrophage markers (CSF1R, MRC1, CD163), and tumor-associated macrophage markers (MARCO, CSF1R, CD40). This evidence concerns the gene NOS2 and neoplasm.