Sun et al. have also found that ACOX1 overexpression weakened the enhancement of miR-15b-5p overexpression on the migration and invasion of CRC cells, and SIRT1/miR-15b5p/ACOX1 axis played an important role in the metastasis of CRC (Sun et al., 2017). The gene discussed is SIRT1; the disease is colorectal carcinoma.