In order to further investigate the prognostic significance of the five-GMRHG prognostic signature in the TP53 mutational status, we conducted a hierarchical survival analysis for TP53-wild and TP53-mutation CRC patients, and found that the overall survival of TP53-mutation CRC patients in the high-risk group was lower than that in the low-risk group with a significant statistical difference (p = 0.001). This evidence concerns the gene TP53 and colorectal carcinoma.