For example, the well-studied, hypomorphic ∆314–315 mutation (Figure 1A; Table 1) impairs Kir2.1 trafficking to the plasma membrane (PM) resulting in Andersen-Tawil syndrome (ATS) (see Sections 2.1-2.3). This evidence concerns the gene KCNJ2 and Cardiodysrhythmic potassium-sensitive periodic paralysis.