GO analysis in the TCGA database showed that several signaling pathways related to immune response were enriched in cluster 2, including positive regulation of natural killer cell-mediated immune response to the tumor cell, negative regulation of IL-6 and mast cell activation, regulation of antigen processing, and presentation, inflammasome and MHC class II protein complex, cyclin A2/CDK2 complex, negative regulation of regulatory T cell differentiation (Figure 3A and Supplementary Figure S2A). This evidence concerns the gene CCNA2 and neoplasm.