Then we further combined the traditional clinical feature of age with the expression levels of hub LMRGs CYP27A1, FAR2, CYP1B1, to construct a nomogram model to predict IDD progression (Figures 7B,C), calibration plots were used to visualize the performance of the nomograms, and the results verified the ability of our model in terms of predicting IDD. Here, CYP1B1 is linked to intervertebral disk degenerative disorder.