KEGG results suggested that some signaling pathways were aberrantly changed in the progression of IDD, including osteoclast differentiation, cytokine-cytokine receptor interactions, NF-κB signaling pathway, toll-like receptor signaling pathway, pyrimidine metabolism, TNF signaling pathway, ferroptosis, etc (Figure 2B). The gene discussed is NFKB1; the disease is intervertebral disk degenerative disorder.