CXCL8 and intervertebral disk degenerative disorder: In current study, a total of 1,053 DEGs were screened, GO analysis displayed that these DEGs were mainly involved in neutrophil activation, regulation of cytokine secretion, regulation of interleukin-8 production, and immune receptor activity, suggesting that the functions of DEGs primarily possessed immune-related functions, and these immune functions were highly correlated with IDD.