UMODL1 and Infertility: Mice overexpressing Umodl1 appear normal at a young age, but they develop premature infertility at the age of six months, possibly by a direct action on ovarian follicles (Wang et al., 2012); moreover, it has been reported that the UMODL1 gene product might play a critical role in susceptibility to high myopia (Nishizaki et al., 2009).