Interestingly, TGF-β inhibition was efficient in Col1a2+/G61°C, and Crtap−/- mice, but not in Col1a1Jrt/+ ones, suggesting different effects of the antibody in different OI types or even different TGF-β activation levels in these OI murine models. This evidence concerns the gene COL1A2 and osteogenesis imperfecta.