TGFB1 and osteogenesis imperfecta: Interestingly, the inhibition of TGF-β signaling by 1D11 was not effective in Col1a1Jrt/+ mice (Tauer et al., 2018), suggesting that the different response to anti-TGF-β treatment depends on the severity of the OI mouse model, which in turn, is determined by the mutation type leading to OI.