NFE2L2 and metabolic dysfunction-associated steatotic liver disease: Moreover, many natural Nrf2 activators such as curcumin, aucubin and ginkgolide B can alleviate NAFLD through the regulation of lipid metabolism and oxidative stress of liver cells, which may be a new prevention and treatment for NAFLD (Figure 4) (Yan et al., 2018a; Shen et al., 2019b; Yang et al., 2020b).