NFE2L2 and primary biliary cholangitis: In order to find out the cytoprotective mechanisms of ursodeoxycholic acid (UDCA) in PBC, Kawata et al. used liver biopsy to compare the liver cell status and Nrf2-mediated antioxidant protein of 13 PBC patients before and after UDCA treatment and collected serological samples for analysis such as serum total bilirubin, alkaline phosphate Enzymes and other indicators.