Therefore, METTL3 overexpression in HCC promotes the development of HCC by binding to the m6A reader proteins YTHDF1 and YTHDF2 and subsequently regulating downstream signaling pathways, which is consistent with the finding that YTHDF1 and YTHDF2 are hub genes in this study. The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.