In this study, we used multiple public databases to reveal that expression levels of METTL3, VIRMA and CBLL1 were significantly increased in the m6A writer complex, while expression levels of METTL14 and ZC3H13 were significantly decreased in HCC, which was closely related to clinicopathological factors, such as tumor stage and prognosis, confirming their potential role as biomarkers for diagnosis and prognosis determination. This evidence concerns the gene METTL3 and hepatocellular carcinoma.