Its components include METTL3, METTL14, WTAP, RBM15/15B, VIRMA, ZC3H13 and CBLL1, as well as other possible components (Gu et al., 2020), which catalyze m6A formation in the mRNA of oncogenes or tumor suppressors and trigger a series of molecular biological effects, which in turn regulates the expression of cancer-related genes (Zaccara et al., 2019) (Figure 1A). The gene discussed is METTL3; the disease is cancer.