Upregulated expression of METTL3, WTAP, RBM15, RBM15B, VIRMA, and CBLL1 and downregulated expression of METTL14 and ZC3H13 are markers of poor prognosis in HCC (Figure 5A), consistent with previous analytic results (Figure 2D). The gene discussed is METTL3; the disease is hepatocellular carcinoma.