Mechanistically, METTL3 increases methylation levels of suppressor of cytokine signaling 2 (SOCS2) mRNA, promotes its degradation through a m6A-YTHDF2-dependent mechanism, and inhibits SOCS2 expression in HCC tissues, thereby promoting HCC progression (Chen et al., 2018). This evidence concerns the gene METTL3 and hepatocellular carcinoma.