In contrast to its upregulation in cholangiocarcinoma and EC (Guo et al., 2021), we found that ZC3H13 acts as a tumor suppressor in HCC, consistent with the findings in breast and ovarian cancer (Zhang et al., 2020b; Wang et al., 2021a), suggesting functional diversity of ZC3H13 in different tumors. This evidence concerns the gene ZC3H13 and hepatocellular carcinoma.